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Weight loss tips

Phentermine weight loss

If you are trying to lose weight and need a medication to help suppress the appetite, reduce cravings and increase metabolism, you probably want to consider one of the most commonly prescribed appetite suppressant medications by weight loss doctors called Adipex or Phentermine.

Although Phentermine or Adipex can be used on its own, many weight loss physicians do use it in combination with other diet pills, such as the combination of Phentermine with Topiramate like in the new diet pill, Qsymia, for additional help to reduce food cravings and for synergistic effect on weight loss.

Phentermine weight loss diet pill - How does Phentermine work? 


Phentermine, like it's cuisine, Phendimetrazine(Bontril) is an Amphetamine based medication that helps you lose weight by helping your metabolism go up. Phentermine helps burn fat and also helps reduce hunger, and increase your resting metabolic rate so that your body is able to reduce caloric intake and increase metabolism so you can lose weight.

How commonly is Phentermine prescribed for weight loss?

Despite the many new weight loss medications now available such as Qsymia (Phentermine and Topiramate), Belviq (Lorcaserin), Saxenda (Liraglutide) and Conrave, Phentermine continues to be the most commonly used and most used weight loss medication or diet pill by most weight loss doctors, also called Bariatricians or obesity medicine doctors. 

Combination of Phentermine with other weight loss medications

Although Phentermine can be used alone to help fight obesity and burn fat, it is increasingly being used with other weight loss medications or diet pills including Topiramate like in Qsymia. 

What is Phentermine?

Related to the broad class of medications generally known as Amphetamines, Phentermine(Adipex) is the most widely used weight loss medication or diet pill in the United States.

Most popular weight loss drug for most weight loss doctors

A 2008 survey of prescribing practices found that 98% of bariatric medicine specialists(medical weight loss doctors) used appetite suppressants or diet pills in treating obesity and that 97% of those prescribed phentermine as their first choice.

What is Phentermine used for?

Phentermine is used for a limited period of time to speed weight loss in overweight or obese people defined as those weight a body mass index of over 25 in addition to diet and exercise as prescribed and supervised by a licensed and experienced weight loss physician. 

How does Phentermine work for weight loss?

Phentermin is an anorectic medication that increases the metabolism and reduces hunger by decreasing appetite. 

There are three main actions of Phentermine:

  1. Phentermine works on the hypothalamus portion of the brain that eventually help stimulate the adrenal glands to release norepinephrine, a neurotransmitter or chemical messenger that signals a fight-or-flight response, reducing hunger. 
  2. Phentermine works also outside the brain, as well, to release epinephrine or adrenaline, causing fat cells to break down stored fat, but the principal basis of efficacy is hunger-reduction. 
  3. Phentermine also releases serotonin and dopamine, but to a much lesser extent than that of norepinephrine.

FDA approval history of Phentermine

As one of the first medications to be approved by the FDA for weight loss, phentermine has been around for over 50 years. Approved in 1959, phentermine hydrochloride is now manufactured by several pharmaceutical companies includingn Gate Pharmaceuticals under the brand name Adipex-P and the less popular brand name Ionamin from Medeva Pharmaceuticals. Phentermine is also currently sold as a generic. Phentermine is a schedule IV drug under the Convention on Psychotropic Substances.[11] In the United States, it is classified as a Schedule IV controlled substance under the Controlled Substances Act. In contrast, amphetamine preparations are classified as Schedule II controlled substances.

Combination of Phentermine with Topiramate Extended Release (Qsymia)

Phentermine is being studied in combination with other medications for obesity. The first such combination is the appetite suppressant phentermine/topiramate (Qsymia formerly Qnexa). In 2012, the FDA approved its sale in the United States and is currently one of the most effective weight loss combinations when the patients are able to tolerate the medication.

Extended release formulation of Phentermine

Phentermine comes as tablets and extended-release capsules. It usually is taken as a single daily dose in the morning or three times a day 30 minutes before meals. 

Duration of therapy of Apidex - P or Phentermine

Originally approved for short term therapy for obesity, phentermine is used for treatment of obesity. However, the FDA has been questioned by many weight loss physicians and physician groups, most notably, the American Society of Bariatric Physicians, as to the rationale in limiting the use of Phentermine for short term use when obesity itself is recognized as a chronic or long term process. Realizing this folly in the original labelling of Phentermine, the US FDA has stated that the newer combination medications such as Qsymia (Phentermine and Topiramate) are approved for long term use although the indication for Phentermine alone remains unchanged. Most weight loss physicians use Phentermine longer term as an off label indication based on idividual patient situation.

Side effects of Phentermine

Generally speaking, phentermine is relatively well tolerated especially in smaller doses and when used under proper clinical supervision with physicians familiar with use of Phentermine.


Common side effects of Adipex - P or Phentermine

Common (>1% incidence) adverse effects include:

  • Xerostomia (dry mouth)
  • Hypertension
  • Diarrhea
  • Vomiting
  • Agitation
  • Restlessness
  • Nervousness
  • Euphoria
  • Arrhythmia
  • Tachycardia
  • Headache
  • Rash
  • Urinary frequency
  • Facial oedema
  • Unpleasant taste
  • Urticaria
  • Impotence
  • Changes in libido

Less common or rare (<1% incidence) adverse effects include:

  • Valvular heart disease (in combination with dexfenfluramine and fenfluramine; causal relationship unclear)
  • Primary pulmonary hypertension
  • Increased seizure activity in people with epilepsy
  • Psychosis
  • Withdrawal symptoms on stopping
  • Dysphoria
  • Ischaemic events

Cautions and Contraindications for use Phentermine

Phentermine use is contraindicated in those who are:

  • Known hypersensitivity or idiosyncratic reaction to sympathomimetic amines
  • Taking amphetamine (i.e., Adderall, Dexedrine, Vyvanse), dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken a monoamine oxidase inhibitor (MAOI) (e.g., phenelzine) in the last 14 days
  • Hyperthyroidism
  • Concomitant treatment with drugs that increase blood pressure
  • Glaucoma
  • Peptic ulcer
  • Prostatic hypertrophy
  • Epilepsy
  • Contraindicated in cardiac disease (e.g. advanced arteriosclerosis, pulmonary hypertension, uncontrolled hypertension, arrhythmias) and cerebrovascular disease (stroke)
  • Pregnant, planning to become pregnant, or are breast-feeding
  • Those receiving serotonergic medications such as the selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitor, tricyclic antidepressant, due to the potential for serotonin syndrome to be precipitated by the cotreatment.

Drug interactions for Phentermine

Medicines which may interact with phentermine, such as dexfenfluramine, fenfluramine, furazolidone, or MAOIs (e.g., phenelzine) are contraindicated because of the risk of serious side effects, such as increasing headache, high blood pressure, slow heart rate, elevated temperature, or possibly fatal lung problems, may be increased. Guanadrel (Hylorel) or guanethidine (Ismelin) effectiveness may be decreased by phentermine. Antacids may decrease the excretion of phentermine. Carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, methazolamide) may decrease the excretion of phentermine.

Trade names

Adipex P (immediate release), Ionamin

Cost of Phentermine at W8MD Weight Loss Clinics - Lowest Cost Adipex

The cost of Phentermine varies. At most W8MD weight loss locations, when and if Phentermine was determined to be a medication appropriate for a particular patient by the weight loss physician after the initial history and physical examination, it may be included in the biweekly program cost of $50.00 includes up to two diet pills, depending on the particular W8MD weight loss center. As most other weight loss clinics that offer Adipex charge much more, for most people, the W8MD weight loss clinics that offer Adipex for appetite suppression ends up being one of the lowest cost weight loss prescription medication for them. Contact the individual location for more information.  

W8MD weight loss physicians are familiar with use of Prescription Adipex or Phentermine and other weight loss medications and can offer this as one of the options to lose weight for eligible patients when medically appropriate in addition to a reduced calorie diet and appetite suppression!

As Adipex lowers the food cravings, increases the fat burning, and metabolism, most patients on Adipex are able to lose weight faster compared to those that do not take this prescription diet pill. 

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