W8MD Weight Loss, Sleep & Aesthetic Services 

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W8MD's NYC Medical Weight Loss, Sleep & Aesthetic Center of New York 

2003, Bath Avenue, Brooklyn, NY, 11214. 

Office of Dr Prab R. Tumpati, MD


Our farthest patient comes from Dallas, Texas! Testimonials

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The W8MD center in New Jersey Is closed as of May 2017.

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Protein shakes for fast weight loss

Protein shakes for fast weight loss - do they work?

Using protein based liquid or solid meal replacements for weight loss has been a clinically proven strategy to help one lose weight and to maintain it. Before we look at how the protein supplements work for fast weight loss results, let us review the science and art of how obesity is treated.

What are the 5 clinically proven measures to lose weight?

How do you treat obesity? What are the clinically proven ways to lose weight?

Obesity is treated using one or more of these clinically proven weight loss strategies: 

∎ a diet low in calories either a Very Low Calorie Diet (VLCD) or Low Calorie Diet (LCD) diet.

∎ increased physical activity in combination with a reduced calorie diet

∎ behavior therapy for changing eating habits

∎ prescription medications or diet pills to suppress hunger, reduce cravings and increase appetite

∎ weight-loss surgery also called bariatric surgery

 Having said the above, now let us review how VLCD and LCD diet plans work and how protein weight loss supplements might help in weight loss.

What is a VLCD Diet for weight loss and why they use protein supplements?

A VLCD is a special weight loss diet that provides up to 800 calories per day under careful physician supervision. 

What makes VLCD diet different from any low calorie diet?

A VLCD diet is previously called Protein Sparing Modified Fast (PSMF) which actually better reflects what this diet is than the new term VLCD diet as it is not just any low calorie or very low calorie diet but a special weight loss diet that is specially formulated with protein and very low in overall calories for fast weight loss results.

Protein powder, protein shakes, protein bars and other weight loss supplements

A very low-calorie diet (VLCD) is not just any diet that is low in calories. It is a special type of diet that replaces all of your meals with prepared formulas, often in the form of liquid shakes. A VLCD may be used for a short time to promote quick weight loss among some people who are considered to be obese. The diet requires close care from your doctor and is usually combined with other ways to lose weight. This fact sheet will tell you more about the risks and benefits of this type of diet. Do not go on a VLCD on your own. If you need to lose weight, talk to your health care provider about the approaches that may work best for you. 

weight loss supplements

Protein shakes, protein bars and other protein weight loss supplements

VLCDs use commercial formulas, usually liquid shakes, soups, or bars, which replace all your regular meals. These formulas are not the same as the meal replacements you can find at grocery stores or pharmacies, which are meant to replace one or two meals a day. Depending on a number of factors, healthy adults need different amounts of calories to meet their daily energy needs. A standard amount is about 2,000 calories. VLCDs provide far fewer calories than most people need to maintain a healthy weight. This type of diet is used to promote quick weight loss, often as a way to jump-start an obesity treatment program. VLCD formulas are designed to provide all of the nutrients you need while helping you lose weight quickly. 

Should I use a VLCD to lose weight? 

Most people who need to lose weight should not use a VLCD. For many of them, a low-calorie diet (LCD) may work better (see box on next page). VLCDs may be used to promote rapid weight loss among adults who have obesity. Health care providers must review risks and benefits on a case-by-case basis. In general, VLCDs are not appropriate for children. In a few cases, they may be used with some adolescents who are being treated for obesity.

What are the health benefits of a VLCD? 

A VLCD may allow you to lose about 3 to 5 pounds per week. This may lead to an average total weight loss of 44 pounds over 12 weeks. Such a weight loss can rapidly improve medical conditions linked to obesity, including diabetes, high blood pressure, and high cholesterol.

What are the benefits of VLCD's rapid weight loss?

The rapid weight loss experienced by most people on a VLCD can be very motivating. Patients who participate in a VLCD program that also includes lifestyle changes may lose about 15 to 25 percent of their initial weight during the first 3 to 6 months. They may maintain a 5 percent weight loss after 4 years if they adopt a healthy eating plan and physical activity habits. 

What are the health risks of a VLCD?

Doctors must monitor all VLCD patients regularly—ideally every 2 weeks in the initial period of rapid weight loss—to be sure patients are not experiencing serious side effects. Many patients on a VLCD for 4 to 16 weeks report minor side effects such as fatigue, constipation, nausea, or diarrhea. These conditions usually improve within a few weeks and rarely prevent patients from completing the program. The most common serious side effect is gallstones. Gallstones, which often develop in people who are obese, especially women, may be even more commonly developed during rapid weight loss. Some medicines can prevent gallstones from forming during rapid weight loss. 

Will I regain the weight? 

Although the long-term results of VLCDs vary widely, weight regain is common. To prevent weight regain, the VLCD should always be combined with other ways to lose weight and with an active follow-up program.

Weight is a long term problem, and treatment should be long term!

For most people who have obesity, the condition is long term and requires a lifetime of attention even after formal methods to treat the obesity end. You may need to commit to permanent changes of healthier eating, regular physical activity, and an improved outlook about food

The Low-calorie Diet (LCD) An LCD limits calories, but not as much as a VLCD.

A typical LCD may provide

∎ 1,000–1,200 calories/day for a woman

∎ 1,200–1,600 calories/day for a man

The number of calories may be adjusted based on your age, weight, and how active you are.

What does LCD diet consist of and can it contain meal replacements?

An LCD usually consists of regular foods, but could also include meal replacements. 

How can the W8MD's weight loss meal replacements help me lose weight?

W8MD's unique, delicious and affordable VLCD meal replacements can be a great tool in helping you lose weight fast and safe! As W8MD Medical Weight Loss Centers weight loss supplements come in many different flavors and varieties including protein powder, protein shakes, ready made protein shakes, protein cereal for breakfast, protein snacks, protein lunch and dinner items, hot teas, protein dessert items, and all kinds of weight loss protein supplements, you will have a wide choice to choose from.

Can I take the W8MD meal replacements along with appetite suppressant medications?

Yes, it is safe to use the VLCD and LCD diet together with any appetite suppressant medications.

How much does the W8MD meal replacement supplements cost?

Although most weight loss programs charge over $5.00 per meal replaced, at most W8MD Medical Weight Loss Centers, the cost of each meal replaced is as low as $2.15 per meal replaced. Compared to grocery food ingredient cost of about $3.00 per meal, our weight loss supplements are not only affordable but can also be a potential cost saving compared to grocery food costs!

How many meals should I replace?

You can replace 2-4 meals in partial meal replacement plans as you are supposed to eat 4-6 small meals overall.

Should I do complete meal replacements or partial meal replacements?

It is up to you to do partial or complete meal replacements although you get more consistent results and less chances for going over caloric intake in complete meal replacements. However, most people find partial meal replacement of 3-4 meals replaced with one self prepared meals to be a bit more practical for them.

What is the evidence for using meal replacement supplements for weight loss?

1. Science of why protein meal replacements are better than standard diets for weight loss - Cheskin LJMitchell AMJhaveri ADMitola AHDavis LMLewis RAYep MALycan TW.

In this study evaluating Efficacy of meal replacements versus a standard food-based diet for weight loss in type 2 diabetesweight loss at 34 weeks and weight maintenance at 86 weeks was significantly better on Portion Controlled Diet versus Standard Diet. Approximately 40% of the Portion Controlled Diet participants lost > or =5% of their initial weight compared with 12% of those on the Standard Diet.


3. Meta-analysis of 6 studies looking at the evidence for partial meal replacements for better weight loss compared to regular diets - Heymsfield SB, van Mierlo CA, van der Knaap HC, Heo M, Frier HI.

This first systematic evaluation of randomized controlled trials utilizing PMR plans for weight management suggests that these types of interventions can safely and effectively produce significant sustainable weight loss and improve weight-related risk factors of disease.

Phentermine and Topiramate

With so many options for suppressing appetite for weight loss, what is the best weight loss medication?

w8md weight loss doctor

The answer to this question depends on your medical situation, preferences, and the experience and training of the prescribing weight loss physician. Having said that, let us review the various weight loss medications in the order of their effectiveness.

Watch a youtube video on the various weight loss medications including Phentermine and Topiramate

By far, the most effective medications for suppressing appetite for losing weight are the combination weight loss medications such as Phetermine and Topiramate. Let us review this very effective weight loss combination of Phentermine and Topiramate a bit further.

Phentermine and topiramate is a combination weight loss medication that was approved as the brand name Qsymia in 2011 by the United States Food and Drug Administration. Phentermine is an amphetamine based, and traditionally, one of the most used weight loss medication. When combined with a low dose of a neuropathy, anti-seizure type medication that is commonly used to treat migraines etc. called Topiramate, there is significant synergy. With this synergy, the expected weight loss with the combination of Phentermine and Topiramate is higher than the sum of the expected weight loss from each of the two individual components used separately, hence the synergy in curbing appetite and helping one lose weight. Partly due to the Topiramate, this combination not only helps suppress the appetite but also takes away cravings for foods, such as carbohydrate, sugar or salt cravings thus reducing food intake and leading to effective and fast weight loss in most patients.

Who should consider Phentermine and Topiramate for losing weight? 

Any adult who is obese defined as a body mass index of 30 or more, or any overweight person with a body mass index of 27 or more with one or more weight related medical problems such as high blood pressure, cholesterol problems, sleep apnea, diabetes etc. Interestingly, this is one of the few weight loss medications that is FDA approved not only to help one lose weight but also to maintain weight as obesity is now recognized as a chronic medical problem that needs long term medical management just like high blood pressure, high cholesterol or other life style related medical conditions. 

This novel combination weight loss medication, Phentermine and topiramate should be used along with a reduced calorie diet and exercise plan. 

What is Phentermine and how does it work for weight loss?

Phentermine is in a class of medications called anorectics. It works by decreasing appetite. 

What is Topiramate and how does it work for weight loss?

Topiramate is in a class of medications called anticonvulsants. It works by decreasing appetite and by causing feelings of fullness to last longer after eating.

How should Phentermine and Topiramate be used?

Phentermine and Topiramate

Phentermine and topiramate is usually taken with or without food once a day in the morning and taken at around the same time every day.

Dose titration of Phentermine and Topiramate

It is recommended to start phentermine and topiramate at a lose dose and increase the dose after 14 days. If need be, the dose can be further titrated at regular intervals until the most effective combination is reached, not to exceed the maximum recommended dose of Phentermine 37.5 mg daily.

 When will I know if Phentermine and Topiramate are working for me?

After you take this combination medication for 12 weeks, the weight loss doctor will check to see how much weight you have lost. If you have not lost a certain amount of weight, the weight loss doctor may tell you to stop taking phentermine and topiramate or may increase the dose. After you take the new dose of Phentermine and Topiramate for 12 weeks, your weight loss doctor will check to see how much weight you have lost. If you have not lost a certain amount of weight, it is not likely that you will benefit from taking phentermine and topiramate, so your doctor will most likely tell you to stop taking the medication.

Control of appetite with Phentermine and Topiramate

Phentermine and topiramate will help control your weight only as long as take the medication. Do not stop taking phentermine and topiramate without consulting with your doctor. If you suddenly stop taking phentermine and topiramate, you may experience seizures due to the Topiramate component, especially if you are at a higher dosage. Your weight loss physician will advise you to decrease your dose gradually and not stop suddenly.

Contra-indications for Phentermine and Topiramate

  • Please let your weight loss doctor know if you are allergic to phentermine (Adipex-P, Suprenza); topiramate (Topamax); sympathomimetic amine medications such as midodrine (Orvaten, ProAmatine) or phenylephrine (in cough and cold medications); any other medications, or any of the ingredients in phentermine and topiramate capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • Please let your weight loss doctor know if you are taking a monoamine oxidase inhibitor (MAOI) including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have taken one of these medications during the past two weeks. Your doctor will probably tell you not to take phentermine and topiramate if you are taking one or more of these medications or have taken one of these medications during the past 2 weeks.
  • Please let your weight loss doctor know what other prescription and nonprescription medications, or supplements.
  • Please let your weight loss doctor know if you have glaucoma (condition in which increased pressure in the eye can cause vision loss) or an overactive thyroid gland. Your doctor will probably tell you not to take phentermine and topiramate.
  • Please let your weight loss doctor know if you have had a heart attack or a stroke in the past 6 months, if you have ever thought about killing yourself or tried to do so, and if you are following a ketogenic diet (high fat, low carbohydrate diet used to control seizures). Also tell your doctor if you have or have ever had depression; an irregular heartbeat; heart failure; seizures; metabolic acidosis (too much acid in the blood); osteopenia, osteomalacia, or osteoporosis (conditions in which the bones are brittle or weak and may break easily); ongoing diarrhea; any condition that affects your breathing; diabetes; kidney stones; or kidney or liver disease.

Pregnancy and Phentermine with Topiramate

Please let your weight loss doctor know if you are pregnant or plan to become pregnant. If you take phentermine and topiramate during pregnancy, your baby may develop a birth defect called cleft lip or cleft palate. Your baby may develop this birth defect very early in the pregnancy, before you know that you are pregnant. You must use birth control to prevent pregnancy during your treatment. You must take a pregnancy test before you begin your treatment and once every month during your treatment. If you become pregnant while taking phentermine and topiramate, stop taking the medication and call your doctor immediately.

How does Phentermine and Topiramate (Qsymia) compare with Belviq?

The other new weight loss medication that was approved around the same time as Phentermine and Topiramate is Belviq(Lorcaserin). Lorcaserin is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic. On 10 May 2012, after a new round of studies submitted by Arena, an FDA panel voted to recommend lorcaserin for patients with a BMI of over 30, or with a BMI over 27 and a comorbidity like high blood pressure or type 2 diabetes. In studies, the combination of Phentermine and Topiramate (Qsymia) showed about 9% weight loss on an average while Belviq showed about half the same in terms of weight loss. In general, Phentermine and Topiramate is considered a bit more effective although it may vary in individuals.

Prevention of pregnancy and contraceptive options

Since Topiramate is known to cause neural tube defects if you get pregnant while taking it, it is recommended that all women of child bearing age should check to make sure they are not pregnant before starting and use double protection throughout the course of treatment.

One can use oral contraceptives (birth control pills) to prevent pregnancy during your treatment with phentermine and topiramate. You may experience unusual spotting (unexpected vaginal bleeding) if you use this type of birth control. You will still be protected from pregnancy if you are spotting, but you can talk to your doctor about other forms of birth control if the spotting is bothersome.

Please let your weight loss doctor know if you are breast-feeding.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking phentermine and topiramate.

Phentermine and topiramate may slow your thinking and movements and affect your vision. Do not drive a car or operate machinery until you know how this medication affects you.

You are advised not to drink alcoholic beverages while you are taking phentermine and topiramate. Alcohol can make the side effects of phentermine and topiramate worse.

Phentermine and topiramate can prevent you from sweating and make it harder for your body to cool down when it gets very hot. Avoid exposure to heat, drink plenty of fluids and tell your doctor if you have a fever, headache, muscle cramps, or an upset stomach, or if you are not sweating as usual.

Mood changes

While the medication combination takes your interest in food, you should know that sometimes your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking phentermine and topiramate.

A small number of adults and children 5 years of age and older (about 1 in 500 people) who took antiepileptics such as topiramate to treat various conditions during clinical studies became suicidal during their treatment although this is rare. If you notice any significant mood changes or suicidal ideation, please talk to your doctor.

What special dietary instructions should I follow?

Drink extra fluids during your treatment with phentermine and topiramate.

What should I do if I forget a dose?

Skip the missed dose and take your usual dose the next morning. Do not take a double dose to make up for a missed one.

What side effects can this medication cause? 

Phentermine and topiramate may cause side effects including but not limited to the following:

  • headache
  • dizziness
  • numbness, burning, or tingling in the hands, feet, face, or mouth
  • decreased sense of touch or ability to feel sensation
  • difficulty concentrating, thinking, paying attention, speaking, or remembering
  • excessive tiredness
  • dry mouth
  • unusual thirst
  • changes or decreased ability to taste food
  • diarrhea
  • constipation
  • heartburn
  • painful menstrual periods
  • pain in the back, neck, muscles, arms or legs
  • tightening of the muscles
  • painful, difficult, or frequent urination
  • hair loss
  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
  • racing or pounding heartbeat that lasts several minutes
  • sudden decrease in vision
  • eye pain or redness
  • fast, shallow breathing
  • severe pain in the pack or side
  • blood in urine
  • rash or blisters, especially if you also have fever
  • hives

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Store phentermine and topiramate in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many capsules are left so you will know if any are missing.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include the following: 

  • restlessness
  • uncontrollable shaking of a part of the body
  • fast breathing
  • confusion
  • aggressiveness
  • hallucinations (seeing things or hearing voices that do not exist)
  • panic
  • excessive tiredness
  • depression
  • irregular heartbeat
  • nausea
  • vomiting
  • diarrhea
  • stomach pain or cramps
  • seizures
  • coma (loss of consciousness for a period of time)
  • dizziness
  • speech disturbances
  • blurred or double vision
  • problems with coordination

What other information should I know about Phentermine and Topiramate?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to phentermine and topiramate. Do not let others take your medication. Giving or selling phentermine and topiramate to others may harm them and is against the law. Phentermine and topiramate is a controlled substances.

Locations for Physicians experienced and familiar with Phentermine and Topiramate, and other weight loss medications

While there may be many doctors that can offer Phentermine and Topiramate, you want to choose those weight loss physicians with experience and are very familiar with the various aspects of these medications. W8MD Medical Weight Loss Centers of America's weight loss physicians are very familiar with these and and other weight loss medications and can recommend the best weight loss solution that is right for you after a consultation with one of our medical weight loss physicians.
Minimal administrative cost of $45.00 biweekly includes two week supply of up to two appetite suppressants at most W8MD Medical Weight Loss Centers including Phentermine, and Topiramate when appropriate!

And we accept insurance for the weight loss physician weight loss visits, unlike the many "cash only" weight loss programs.t(LCD) for fast weight loss* with delicious meal replacements

Philadelphia Insurance Weight Loss & Sleep Center: 1718, Welsh Rd, Philadelphia, PA, 19115 Ph: 1-215-676-2334 

Philadelphia weight loss doctor

King Of Prussia Weight Loss & Sleep Center: 987 Old Eagle School Rd, Ste 712, Wayne, PA, 19087 Ph: 215-676-2334 

Philadelphia weight loss doctor

NYC Insurance Weight Loss & Sleep Center: 2003, Bath Avenue, Brooklyn, NY, 11214 Ph: 1-718-946-5500. 

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Grand opening of W8MD weight loss program in New Jersey on 10/29/2014.

Related articles

FDA approves Contrave for weight loss

The United States Food and Drug Administration approved Contrave, a combination of naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment option for chronic weight management in addition to a reduced-calorie diet and physical activity.

Indications for use of Contrave weight loss medication

Contrave is approved for use in adults with a body mass index (BMI) of 30 or greater (obesity) or adults with a BMI of 27 or greater (overweight) that have at least one weight-related comorbidity such as high blood pressure (hypertension), type 2 diabetes, sleep apnea, metabolic syndrome or high cholesterol (dyslipidemia).

Body Mass Index

Body Mass Index or BMI, measures body fat based on an individual’s weight and height, is used to define the obesity and overweight categories. According to the Centers for Disease Control and Prevention, more than one-third of adults in the United States are obese defined as a BMI of 30 or over and another third are in the overweight category as noted below.

CDC Adult Obesity Rate

  • Percent of adults age 20 years and over who are obese: 35.1% (2011-2012)
  • Percent of adults age 20 years and over who are overweight, including obesity: 69.0% (2011-2012)

Source: Health, United States, 2013, table 64 Adobe PDF file [PDF - 9.8 MB]

CDC Children and adolescents

  • Percent of adolescents age 12-19 years who are obese: 18.4% (2009-2010)
  • Percent of children age 6-11 years who are obese: 18.0% (2009-2010)
  • Percent of children age 2-5 years who are obese: 12.1% (2009-2010)

Obesity is a Major Public Health Problem

“Obesity continues to be a major public health concern,” according to Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA’s Center for Drug Evaluation and Research. “When used as directed in combination with a healthy lifestyle that includes a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and have at least one weight-related health condition.”

What is Contrave?

Contrave is a combination of two FDA-approved drugs that have been on the market for quite sometime, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence and Bupropion is approved to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment. However, the combination of these two medications is now approved for weight loss.

Clinical efficacy of Contrave for weight loss

The effectiveness of the weight loss drug Contrave was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical activity in addition to the weight loss medication contrave.

How much weight loss was expected with Contrave?

Results from a clinical trial that enrolled non-diabetic patients showed that patients had an average weight loss of 4.1 percent over treatment with placebo at one year. In this trial designed to assess the efficacy of contrave for weight loss, 42 percent of patients treated with Contrave lost at least 5 percent of their body weight compared with 17 percent of patients treated with placebo. Results from another clinical trial that enrolled patients that have type 2 diabetes showed that patients had an average weight loss of 2 percent over treatment with placebo at one year. In this trial, 36 percent of patients treated with Contrave lost at least 5 percent of their body weight compared with 18 percent of patients treated with placebo.

How does Contrave Compare to Qsymia and Belviq?

In general, Contrave (Naletrexone/Bupropion) is likely to be less effective than Qsymia, a bit more effective than Belviq as trials of those taking Qsymia lost an average of 9 percent of their body weight, while those taking Belviq lost an average of just 3 percent. Clinical trials show those taking Contrave lost an average of 5 percent of their body weight in the same period.

So, 9 percent of weight loss for Phentermine/Topirmate (Qsymia), 5 percent for Bupropion/Naltrexone(Contrave) and 3 percent for Lorcaserin(Belviq)!

12 week trial

Patients using Contrave at the maintenance dose should be evaluated after 12 weeks to determine if the treatment is working. If a patient has not lost at least 5 percent of baseline body weight, Contrave should be discontinued, as it is unlikely that the patient will achieve and sustain clinically meaningful weight loss with continued treatment.

Standard Boxed Warning Related to Bupropion

Because it contains bupropion, Contrave has a boxed warning to alert health care professionals and patients to the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs although in clinical practice this is not seen that often. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.


Contrave can cause seizures and must not be used in patients who have seizure disorders. The risk of seizure is dose-related. Contrave should be discontinued and not restarted in patients who experience a seizure while being treated with Contrave. 

Contrave can also raise blood pressure and heart rate and must not be used in patients with uncontrolled high blood pressure. The clinical significance of the increases in blood pressure and heart rate observed with Contrave treatment is unclear, especially for patients with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease, since patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Blood pressure and pulse should be measured prior to starting the drug and should be monitored at regular intervals, particularly among patients with controlled high blood pressure prior to treatment. 

Other products containing bupropion should not be taken along with Contrave. The drug should not be used in patients who have eating disorders (bulimia or anorexia nervosa). Contrave should also not be taken by patients who are using opioids or treatments for opioid dependence, or who are experiencing acute opiate withdrawal. Patients undergoing an abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs should not take Contrave.  Women who are pregnant or trying to become pregnant should not take Contrave.

Adverse reactions to Contrave

The most common adverse reactions reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

Post Marketing Requirements

The FDA is requiring the following post-marketing requirements:

  • a cardiovascular outcomes trial to assess the cardiovascular risk associated with Contrave use;
  • two efficacy, safety, and clinical pharmacology studies in pediatric patients (one in patients 12 to 17 years of age, and one in patients 7 to 11 years of age);
  • a nonclinical (animal) juvenile toxicity study with a particular focus on growth and development as well as behavior, learning, and memory;
  • a study to evaluate the effect of Contrave on cardiac conduction;
  • clinical trials to evaluate dosing in patients with hepatic or renal impairment;
  • a clinical trial to evaluate the potential for interactions between Contrave and other drugs.

Distribution in USA

Contrave is distributed by Takeda Pharmaceuticals America Inc. of Deerfield, Illinois for Orexigen Therapeutics, Inc. of La Jolla, California.

The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products

Price of Contrave

Contrave is probably the most cost effective of the three new weight loss medications approved in the last few years, the other two being Qsymia, Belviq. The other new medications Belviq and Qsymia can cost up to $150-225 dollars per month.

Costing about $70.00 dollars a month without insurance first two months, drops to $60.00 thereafter, contrave is very cost effective. For those that have insurance, the maximum monthly cost is $55.00 for the first two months that drops to $45.00 after the first two months.

Estimated Sales Figures

As of 2014, the drug is marketed in the United States in a sustained release formulation under the name Contrave by Takeda for the drug's developer, Orexigen Therapeutics. An estimate from Wells Fargo places the potential revenue from this drug at US$600 million per year.

FDA Filing History

On 31 March 2010, Orexigen submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for this drug combination. On 7 December 2010, an FDA Advisory Committee voted 13-7 for the approval of Contrave, and voted 11-8 for the conduct of a post-marketing cardiovascular outcomes study.[8] Contrave's PDUFA date was 31 January 2011. Subsequently, on 2 February 2011, the FDA rejected the drug and it was decided that an extremely large-scale study of the long-term cardiovascular effects of Contrave would be needed, before approval could be considered. The recommended daily dose of Contrave is two (8 mg naltrexone/90 mg bupropion) tablets taken twice daily (4 tablets total - 32 mg naltrexone, 360 mg bupropion). Upon initiation, the drug will be started with a quarter-dose (or one tablet) for one week and a pill will be added to the regimen each week until the full recommended dose is reached on Week 4.

 How does Contrave Work for weight loss?

Treatment is designed to influence the hypothalamus in order to decrease food intake over an extended period of time. Studies of almost 700 patients, 90% female, ran up to 56 weeks. The control group, overall, lost 5% of their initial body weight, or 11-16 lbs. The experimental (medicated) group lost 20-23 lbs during the same amount of time. The average starting weight for participants was 223 lbs. Current medical weight loss medications average 5-22 lbs lost in 6 months.

 Availability of Contrave weight loss medication

W8MD Medical Weight Loss Centers of America is one of the first weight loss programs to start offering Contrave for eligible patients to help lose weight and is available at their weight loss locations in New York, Pennsylvania and New Jersey. Call W8MD today at 1-800-W8MD-007 to learn more or to setup a consultation. As one of the very few medical weight loss centers that accepts health insurance for the physician weight loss visits, W8MD gets patients from far and near including other states!

Philadelphia weight loss doctor

King Of Prussia Weight Loss & Sleep Center: 987 Old Eagle School Rd, Ste 712, Wayne, PA, 19087 Ph: 215-676-2334 

If you are looking for Doctors in New York City that prescribe Contrave, you may want to contact the New York City W8MD medical weight loss center location at 718-946-5500.

Philadelphia weight loss doctor

NYC Insurance Weight Loss & Sleep Center: 2003, Bath Avenue, Brooklyn, NY, 11214 Ph: 1-718-946-5500. 

Contrave doctors in New Jersey

For those living in New Jersey looking to try Contrave, please contact the W8MD weight loss program will be offered soon at Vida Sleep Center of Dr. Felix Roque's office at 543, 45th Street, Union City, New Jersey. 543 45th St, Union City, NJ  07087Phone: (201) 766-6469. 


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Cities Served for weight loss, sleep and Medical Aesthetics

Philadelphia weight loss centersPhiladelphiaKing Of PrussiaWarminster, Wayne, Norristown, Exton, West Chester, Lansdale, Pottstown, Bensalem, Norriton, Phoenixville, Collegeville, Ardmore, Drexel Hill, Springfield, Lansdale, Darby, Horsham, Willow Grove, Abington, Doylestown, Jenkintown etc.
New York City Weight Loss Brooklyn NYC weight Loss, Staten Island, Manhattan, Long Island, West Hempstead, Franklin Square, NY, Hempstead, NY, Garden City, New Hyde Park, Uniondale, North Valley Stream,  New York City, Queens, Bronx, NYC, Bayonne
Counties Served: Philadelphia, Delaware, Chester, Bucks, Montgomery, Burlington, Kings, Richmond, Queens, Manhattan, Bronx, Nassau county NY, Hudson County, NJ


Locations for W8MD sleep, weight loss and medical aesthetics / MedSpa

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W8MD medical weight loss centers of America is designed to provide general information on our insurance physician weight loss program locations, and general weight loss information. W8MD medical weight loss website or any of our affiliated weight loss blogs is not intended to diagnose, treat, cure, or prevent any disease. Also note insurance coverage may vary based on your plan, deductibles, co-insurance etc. and our participation in your plan. Contact your insurance carrier for your coverage details. 

Individual results may vary. No expressed or implied warranties!

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